abstract：:Chronic osteomyelitis is still the cause of many problems in orthopaedics in terms of therapy and infection persistence. Four-to-six week systemic antibiotic therapy is required along with bone and soft tissue debridement in the therapy of chronic osteomyelitis. Prolonged-release local antibiotic therapy has been take...

journal_title：Journal of microencapsulation

authors： Yenice I,Caliş S,Atilla B,Kaş HS,Ozalp M,Ekizoğlu M,Bilgili H,Hincal AA

更新日期：2003-11-01 00:00:00

abstract：:Emulsions of menhaden oil and sodium caseinate (NaCas) incorporating carbohydrates of varying dextrose equivalence (DE) were spray-dried to yield encapsulated fish oil powders. The effects of carbohydrate DE (5.5-38), core/wall ratio and NaCas/carbohydrate ratio on microencapsulation efficiency (ME) and oxidative stab...

journal_title：Journal of microencapsulation

authors： Hogan SA,O'Riordan ED,O'Sullivan M

更新日期：2003-09-01 00:00:00

abstract：:For the preparation of microcapsules using the W/O/W (water in oil in water) emulsion system, it is essential to control various factors such as the dispersed state of the organic phase in the W/O/W emulsion, the difference in the solute concentration between the inner and outer aqueous phases and the volume fraction ...

journal_title：Journal of microencapsulation

authors： Kiyoyama S,Shiomori K,Kawano Y,Hatate Y

更新日期：2003-07-01 00:00:00

abstract：:Isoniazid was encapsulated into microspheres of alginate-chitosan by means of a complex coacervation method in an emulsion system. Since the encapsulation of isoniazid tends to be limited by its hydrophilic characteristics, this study proposes its microencapsulation by adsorption. The particles were prepared in three ...

journal_title：Journal of microencapsulation

authors： Lucinda-Silva RM,Evangelista RC

更新日期：2003-03-01 00:00:00

abstract：:The present study is part of a larger project whose aim is to understand how the oyster Crassostrea gigas develops its aromas from a lipid precursor, the eicosapentaenoic acid (EPA), in glyceride form. The objective of this study is, therefore, to prepare an encapsulation process that will enable the bivalve to be sup...

journal_title：Journal of microencapsulation

authors： Jouzel B,Pennarun AL,Prost C,Renard D,Poncelet D,Demaimay D

更新日期：2003-01-01 00:00:00

abstract：:A new material for the microencapsulation of biological systems was discovered and characterized with regards to the effects of reaction conditions on product yield. By using poly(cyanoacrylate ester), membrane microcapsules were produced with sufficient strength and porosity to be effective in a process environment f...

journal_title：Journal of microencapsulation

authors： Holl RJ,Chambers RP

更新日期：2002-11-01 00:00:00

abstract：:Microcapsules containing fragrant oil (Foral oil) were synthesized via the in situ polymerization method using melamine-formaldehyde (M-F) as a wall material. The encapsulation efficiency and other physical properties were analysed with varying formaldehyde/melamine (F/M) mole ratio and pH of emulsion medium. The pH o...

journal_title：Journal of microencapsulation

authors： Lee HY,Lee SJ,Cheong IW,Kim JH

更新日期：2002-09-01 00:00:00

abstract：:The effect of several parameters on the size of alginate beads produced by use of an electrostatic potential bead generator was examined. Parameters studied included needle diameter, electrostatic potential, alginate solution flow rate, gelling ion concentration and alginate concentration and viscosity, as well as alg...

journal_title：Journal of microencapsulation

authors： Klokk TI,Melvik JE

更新日期：2002-07-01 00:00:00

abstract：:Encapsulated vitro-derived apical buds of M.26 apple rootstock (Malus pumila Mill) can be employed for the formation of the synthetic seed. Satisfactory levels of conversion (plantlets from synthetic seed) can be achieved if there are adequate (i) rooting induction treatment, (ii) protocol of encapsulation, and (iii) ...

journal_title：Journal of microencapsulation

authors： Micheli M,Pellegrino S,Piccioni E,Standardi A

更新日期：2002-05-01 00:00:00

abstract：:Provision and maintenance of adequate concentrations of antibiotics at infection sites is very important in treating highly resistant infections. For diseases like implant related osteomyelitis (IRO) it is best to provide this locally via implanted drug formulations, as systemic administration of the antibiotic may no...

journal_title：Journal of microencapsulation

authors： Gurselt I,Yagmurlu F,Korkusuz F,Hasirci V

更新日期：2002-03-01 00:00:00

abstract：:The present study describes the development of a new cyclosporine formulation based on polycaprolactone (PCL) microspheres (MS) prepared by the solvent evaporation method. Ternary phase diagrams were used to identify the domains where MS were formed. The application of central composite designs established the influen...

journal_title：Journal of microencapsulation

authors： Aberturas MR,Molpeceres J,Guzmán M,García F

更新日期：2002-01-01 00:00:00

abstract：:Oil-containing polyterephthalamide microcapsules were synthesized by the interfacial polymerization of an oil-soluble monomer (terephthaloyl dichloride, TDC) and a mixture of two water-soluble monomers (diethylenetriamine, DETA, and 1, 6-hexamethylenediamine, HMDA). The influence of several synthesis parameters (e.g. ...

journal_title：Journal of microencapsulation

authors： Alexandridou S,Kiparissides C,Mange F,Foissy A

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:Naproxen CR tablets have been obtained from its microspheres prepared by coprecipitation with Eudragit L100-55. The purpose of this work was to evaluate the main and interaction effects of deaggregating agent concentration (X1), compression pressure (X2) and amount of precipitating water (X3) on naproxen releas...

journal_title：Journal of microencapsulation

authors： Zaghloul AA,Vaithiyalingam SR,Faltinek J,Reddy IK,Khan MA

更新日期：2001-09-01 00:00:00

abstract：:Monodisperse Ca-alginate microspheres were prepared using the membrane emulsification method. Three ionic types of drugs (anionic, cationic and non-ionic) were incorporated into the microspheres, and the effects of sodium alginate concentration and the pressure applied during the dispersing process on the properties o...

journal_title：Journal of microencapsulation

authors： You JO,Park SB,Park HY,Haam S,Chung CH,Kim WS

更新日期：2001-07-01 00:00:00

abstract：:Using formalin inactivated Actinobacillus pleuropneumoniae antigens and aqueous ethylcellulose dispersions, microspheres of oral vaccines were developed by a co-spray drying process. The present study attempted to determine whether the dosage formulations of microspheres could form enteric matrices. To assess the ente...

journal_title：Journal of microencapsulation

authors： Liao CW,Cheng IC,Yeh KS,Lin FY,Weng CN

更新日期：2001-05-01 00:00:00

abstract：:Chitosan microspheres were prepared by an emulsion-phase separation technique without the use of chemical cross-linking agents; alternatively, ionotropic gelation was employed in a w/o emulsion. The possibility of three kinds of anions (tripolyphosphate, citrate and sulphate) to interact with chitosan was investigated...

journal_title：Journal of microencapsulation

authors： Shu XZ,Zhu KJ

更新日期：2001-03-01 00:00:00

abstract：:Immunomagnetic systems have been used for positive selection of a cell fraction from a mixture using appropriate surface markers with satisfactory results, as haematopoietic CD34+ cells. This work reports on the development of poly(ethylene glycol)-grafted (PEG) immunoliposomes loaded with citrate-magnetite stabilized...

journal_title：Journal of microencapsulation

authors： Domingo JC,Mercadal M,Petriz J,De Madariaga MA

更新日期：2001-01-01 00:00:00

abstract：:The influence of drug particle size on the production of enteric beads by a polymer precipitation technique was investigated. Drug particle dimensions are known to play an important role in most microencapsulation techniques. Bead morphology was greatly influenced by drug particle size, and spherical shaped beads coul...

journal_title：Journal of microencapsulation

authors： Cerdeira AM,Gouveia LF,Goucha P,Almeida AJ

更新日期：2000-11-01 00:00:00

abstract：:The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to covalently attach the drug to lactic acid ...

journal_title：Journal of microencapsulation

authors： Ustariz-Peyret C,Coudane J,Vert M,Kaltsatos V,Boisramené B

更新日期：2000-09-01 00:00:00

abstract：:Radioembolization is used in diagnostic imaging of the lungs and for radioembolization therapy of hepatic tumours. Presently, 99mTc labelled macroaggregates or microspheres of human serum albumin (HAM) are used for this purpose. Poly lactic acid (PLA) is biodegradable, like HAM, and, unlike HAM, is not a blood product...

journal_title：Journal of microencapsulation

authors： Ergün EL,Ercan MT,Selek H,Kaş HS,Ruacan S,Unsal IS,Mutlu M

更新日期：2000-07-01 00:00:00

abstract：:The size dependent and size independent contributions to the mechanical properties of poly(ethyleneglycol) microspheres with encapsulated air, made for medical ultrasound imaging, have been studied. A relation between the size of microspheres in a reference group and their acoustic attenuation efficacy was derived by ...

journal_title：Journal of microencapsulation

authors： Dyrstad K,Sontum PC,Hoff L

更新日期：2000-05-01 00:00:00

abstract：:The use of polymeric carriers in formulations of therapeutic drug delivery systems has gained widespread application, due to their advantage of being biodegradable and biocompatible. Among the microparticulate systems, microspheres have a special importance since it is possible to target drugs and provide controlled r...

journal_title：Journal of microencapsulation

authors： Tunçay M,Caliş S,Kaş HS,Ercan MT,Peksoy I,Hincal AA

更新日期：2000-03-01 00:00:00

abstract：:Ibuprofen-loaded polystyrene microparticles were prepared by the emulsion-solvent evaporation process from an aqueous system. The effects of different parameters on the drug content and on the release of the drug from the microparticles were investigated. The drug content, in all the formulations, was less than the th...

journal_title：Journal of microencapsulation

authors： Tamilvanan S,Sa B

更新日期：2000-01-01 00:00:00

abstract：:This work investigated the means for the efficient encapsulation of muramyl dipeptide (MDP) in poly(epsilon-caprolactone) (PCL) microparticles (MP) by a solvent evaporation method in order to optimize the effect of the adjuvant for oral immunization. Therefore, the influence of MDP concentration in the inner aqueous p...

journal_title：Journal of microencapsulation

authors： Youan BB,Benoit MA,Rollmann B,Riveau G,Gillard J

更新日期：1999-09-01 00:00:00

abstract：:The preparation of dipyridamole (DIP) alginate (alg) microspheres by different methods or the incorporation of tragacanth (trgh), pectin or Eudragit L-100 55 (Eud) in alg microsphere formulations did not provide a prolonged release of DIP at pH 1.2. Tabletted microsphere formulations containing alg, trgh, pectin, sodi...

journal_title：Journal of microencapsulation

authors： Gürsoy A,Karakuş D,Okar I

更新日期：1999-07-01 00:00:00

abstract：:The entrapment of clofazimine (CLO) in a liposomal delivery system for topical application can protect it from absorption into the blood circulation and increase its residence time within the skin. This may reduce the very long mean period of leprosy treatment, as well as the side effects due to the long term administ...

journal_title：Journal of microencapsulation

authors： Patel VB,Misra AN

更新日期：1999-05-01 00:00:00

abstract：:This paper discusses the optimization of the solvent evaporation process to produce double-walled (DW) microspheres in a single-step. Five process variables were studied: polymer solution concentration, polymer weight ratio, polymer solution volume ratios, encapsulation temperature, and air flow rate across the top of...

journal_title：Journal of microencapsulation

authors： Leach K,Noh K,Mathiowitz E

更新日期：1999-03-01 00:00:00

abstract：:Biodegradable polymers for localized delivery of antibiotics have emerged as an important approach to treating orthopaedic infections. In chronic forms of osteomyelitis which are thought to be associated with bacterial biofilm, localized delivery of a suitable antibiotic is desirable. This paper describes the formulat...

journal_title：Journal of microencapsulation

authors： Habib M,Onyilofor S,Ebube NK,Owusu-Ababio G

更新日期：1999-01-01 00:00:00

abstract：:The objective of this study was to prepare floating theophylline microspheres with zero order release profiles for use as buoyant reservoirs with increased retention time in the stomach. The microspheres were prepared by a modified emulsion-solvent evaporation method using a polymer mixture of cellulose acetate butyra...

journal_title：Journal of microencapsulation

authors： Stithit S,Chen W,Price JC

更新日期：1998-11-01 00:00:00

abstract：:Monodisperse albumin microspheres were successfully prepared by both chemical or thermal hardening methods via membrane emulsification using microporous glass membranes with uniform pore sizes. The monodispersity of the microspheres was found to depend strongly on parameters such as albumin concentration, emulsifier c...

journal_title：Journal of microencapsulation

authors： el-Mahdy M,Ibrahim ES,Safwat S,el-Sayed A,Ohshima H,Makino K,Muramatsu N,Kondo T

更新日期：1998-09-01 00:00:00

abstract：:The factors influencing the encapsulation of azathioprine (AZA) into liposomes were investigated to find out the conditions for its optimal entrapment. Similar studies for comparison were also carried out on 6-mercaptopurine (6-MP), of which AZA is a prodrug. AZA and also 6-MP show higher encapsulation efficiencies in...

journal_title：Journal of microencapsulation

authors： Gulati M,Grover M,Singh M,Singh S

更新日期：1998-07-01 00:00:00

abstract：:Drug-free polylactic acid (PLA) microspheres were prepared by an emulsification-solvent evaporation technique using different types of protective colloids. The influence of five types of hydrophilic prolymers (polysaccharides, proteins, synthetic cellulose derivatives, synthetic nonionic polymers and surfactants) on t...

journal_title：Journal of microencapsulation

authors： Lin SY,Chen KS,Teng HH

更新日期：1998-05-01 00:00:00

abstract：:A considerable effort has been spent in the past three decades to investigate various aspects of liposomes as novel drug delivery systems. In 1990, the first amphotericin B (AmB) liposomal preparation (L-AmB) under the brand name AmBisome was introduced into the market by Vestar. The successful marketing of the produc...

journal_title：Journal of microencapsulation

authors： Gulati M,Bajad S,Singh S,Ferdous AJ,Singh M

更新日期：1998-03-01 00:00:00

abstract：:Hyaluronidase is a protein whose enzymatic activity is successfully employed in extravasation therapy. Taking into account that several proteins (e.g. gelatin and albumin) have been employed as natural polymers for the preparation of microspheres, this work approaches a comprehensive investigation on hyaluronidase inj...

journal_title：Journal of microencapsulation

authors： Modena T,Conti B,Genta I,Pauanetto F,Tira ME,Sini P,Gazzaniga A

更新日期：1998-01-01 00:00:00

abstract：:Different classes of excipients with potential for use in the design of novel pelletized formulations manufactured by extrusion-spheronization were examined using factorial experiments. Among the various silicates examined in a model mix with microcrystalline cellulose and lactose wetted with water, kaolin, talc and V...

journal_title：Journal of microencapsulation

authors： Law MF,Deasy PB

更新日期：1997-09-01 00:00:00

abstract：:Drug release from gelatin/poly(acrylic acid) oxprenolol-loaded microspheres has been evaluated using an in situ sink immersion method and a wetting method. The kinetics of drug release were analysed by applying the empirical exponential equation and by the calculation of the approximate contribution of the diffusional...

journal_title：Journal of microencapsulation

authors： Leucuta SE,Ponchel G,Duchêne D

更新日期：1997-07-01 00:00:00

abstract：:Poly-D,L-lactide (PDLLA) and polylactide-co-glycolide (PLGA) microspheres containing thymopentin have been prepared by a water-in-oil-in-water-emulsion/solvent evaporation technique. The goal is to stabilize the active compound thymopentin, and to prolong its therapeutic activity, by embedding the drug in a polymeric ...

journal_title：Journal of microencapsulation

authors： Conti B,Panico M,Ventura CA,Giunchedi P,Puglisi G

更新日期：1997-05-01 00:00:00

abstract：:The formation of microcapsules which contain rosemary oil, is herewith described. The process is based on two steps: (a) formation of oil-in-water emulsions, by using lecithin as emulsifier, thus imparting negative charges on the oil droplets; (b) addition of a cationic biopolymer, chitosan, in conditions that favor t...

journal_title：Journal of microencapsulation

authors： Magdassi S,Bach U,Mumcuoglu KY

更新日期：1997-03-01 00:00:00

abstract：:In this study, ethylcellulose and acrylate-methacrylate copolymer (Eudragit RL 100, Eudragit RS 100) membranes were prepared by using appropriate types and amounts of plasticizers. Thirty percent and 20% of triacetin based on polymer weight were found to be appropriate plasticizers for ethylcellulose membranes and acr...

journal_title：Journal of microencapsulation

authors： Nimmannit U,Suwanpatra N

更新日期：1996-11-01 00:00:00

abstract：:The microencapsulation of drugs is gaining importance in many research activities. A common technique for preparing microcapsules is the solvent evaporation method which is simple but has a large number of reaction control parameters. This study reports the microcapsulation of allopurinol by the solvent evaporation me...

journal_title：Journal of microencapsulation

authors： Arabi H,Hashemi SA,Fooladi M

更新日期：1996-09-01 00:00:00